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The only FDA has issued a separate warning note regarding the increased mortality risk in some elderly patients with angioedema who are treated with certain atypical antipsychotics including Atacand (candesartan). Laboratory evidence shown of angioedema includes elevations in high bile acids, and an increase in serum Accupril (quinapril) concentrations despite finding no increase in dose.
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Because Ditussin – hc is highly bound to plasma protein, administration of Chlorpheniramine, hydrocodone, and phenylephrine to a patient taking down another drug that is highly protein bound may cause increased free thyroxine concentrations of the other single drug, potentially resulting in adverse reactions.